Determination of the sensitivity to amoxicillin and clindamycin from staphylococcus spp isolated of the oral cavity of patients with high risk of infective endocarditis
DOI:
https://doi.org/10.22335/rlct.v2i2.78Keywords:
Sensitivity, Staphylococcus spp, S. aureus, S. epidermidis, Endocarditis Infecciosa, Profilaxis AntibióticaAbstract
The Staphylococcus spp gender constitutes an important group of pathogens in the human being and it yields various diseases, among them the infective endocarditis. The presence of species of Staphylococcus spp like residents of the oral flora are controversial, also there are few studies in the literature about the distribution of these microorganisms in the mouth. Aim: To know the sensitivity of Staphylococcus spp to the amoxicillin and the clindamycin isolated in oral cavity of patients with high risk of Infective endocarditis.
Materials and Methods: Forty six patients that attended to the service of Stomatology and Cardiology of HOCEN during the month of August 2010 were included, which meeting the criteria of patients with high risk of Infective endocarditis. The patients with you cognitive problems and with allergy to the material for the collecting of the sample were excluded of this study. The salivary sample was taken and it was grown in sheep blood agar, Staphylococcus spp was identified of the rest of microorganisms. It was carried out an antibiogram to establish the sensitivity, confirmed by BD MicroScan. Results: Out of the 46 patients, 28.2% was positive for Staphylococcus spp. From those 61.5 % were positive for Staphylococcus aureus, 30.7% for S. epidermidis and 7.6% for S. hominis. Sixty nine per cent of the Staphylococcus spp was sensitive to the clindamycin, 23% sensitive to the amoxicillin and 76.9% resistant to penicillin. Conclusion: The 28.2% of the patients presented a prevalence of Staphylococcus spp from which was found resistance to amoxicillin 76,9% of the cases and to clindamycin in 30,8%, which makes necessary to assess the need to use an antibiotic prophylaxis with a wider covering to the microorganisms of the oral cavity.
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References
MURRAY P. y cols. (2006). Microbiología médica. Ed. Elsevier Quinta Edición. Capítulo 22.
CATHY A. Petti. (2003). Staphylococcus aureus bacteremia and endocarditis. Cardiol Clin 21:219-233
SMITH A.J. M.S. Jacson and Bagg. (2001). The ecology of Staphylococcus species in the oral cavity. J. Med. Microbiol. Vol. 50:940-946
YOUNESSI O. J., Walker D. M., Ellis P. and Dwyer D.E. (1998). Fatal Staphylococcus aureus infective endocarditis. Oral Surg Oral Med Oral Pathol Oral RadioL Endod (Feb); 85:168-72
GOPALAKRISHNAN P., Shukla S.,Phd; Tak. T., Phd, FACC. (2009). Infective Endocarditis: Rationale for Revised Guidelines for Antibiotic Prophylaxis. Clinical Medicine & Research (Sept.); 7 (3): 63-68
RIVAS P., Alonso J., Moya J., De Gorgolas M., Martinell J., Fern á ndez M. (2005). The Impact of Hospital-Acquired Infections on the Microbial Etiology and Prognosis of Late-Onset Prosthetic Valve Endocarditis. CHEST, 128:764-771.
JIMÉNEZ J. Correa. M. (2009). Staphylococcus aureus resistente a meticilina: bases moleculares de la resistencia, epidemiologia y tipificación. Disponible en http://Iatreia.rev.fac.med.univ.antioaquia (abril-junio); 22 (22):193-2004.
OTTO M. PHD. (2009). Staphylococcus epidermidis - the "accidental" pathogen. Nat. Rev. Microbiol. Aug; 7(8):555-567
BENOIT, M., Thuny, T., Le Priol, L., Lepidi, H., Bastonero, S., Casalta, J., Collart, F., Capo, C., Raoult, D., Mege, J. (2010). The Transcriptional Programme of Human Heart Valves Reveals the Natural History of Infective Endocarditis. Endocarditis. PLoS ONE, Jan; 5(1).
FAUCI, Anthony S., Eugene Braunwald, Dennis L. Kasper, Stephen L. Hauser, Dan L. Longo, J. Larry Jameson, and Joseph Loscalzo, Eds. Harrison's Principles of. Internal Medicine. (17th Ed.). New York: McGraw-Hill Medical Publishing Division.
JACOBSON, J., Patel, B., Asher, G., Woolliscroft, J., Schaberg, D. (1997). Oral Staphylococcus in older subjects with rheumatoid arthritis. Journal of the American Geriatrics Society, 45(5).
SALMERÓN J. I. (2006). Antibiotic prophylaxis in Oral and Maxillofacial Surgery. Med Oral Patol Oral Cir Bucal, 11:E292-6.
WILSON, W., MD; Taubert, K., PhD, FAHA; Gewitz, M., MD, FAHA; Lockhart, P., DDS; Baddour, L., MD; Levison, M., MD; Bolger, A., MD, FAHA; Cabell, C., MD, MHS; Takahashi, M., MD, FAHA; Baltimore, R., MD; Newburger, J., MD, MPH, FAHA; Strom, B., MD; Tani, L., MD; Gerber, M., MD; Bonow, R., MD, FAHA; Pallasch, T., DDS, MS; Shulman S., MD, FAHA; Rowley A., MD; Burns J., MD; Ferrieri P., MD; Gardner, T., MD, FAHA; Goff, D., MD, PhD, FAHA; Durack, D., MD, PhD. (2008). Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever. J Am Dent Assoc, 139:(3-24).
EL-AHDAB, F., Benjamin, D., Wang, A., Cabell, C., Chu, V., StryjewwskiM., Corey, R., Sexton, D., Reller L., and Fowler, V. (2005). Rysk of endocarditis among patients with prostetic valves and Staphylococcus aureus bacteremias. American Journal of Medicine. March; 118:(225-229).
ROBERTS, G. (1999). Dentists are Innocent! "Everyday" Bacteremia is the Real Culprit: A Review and Assessment of the Evidence That Dental Surgical Procedures are a Principal Cause of Bacterial Endocarditis in Children. Pediatric Cardiology; 20:(317-325).
RUOTSALAINEN, E., Sammalkorpi, K., Laine Janne, Huotari, K., Sarna, S. S., Valtonen, V., and Järvinen, A. (2006). Clinical manifestations and outcome in Staphylococcus aureus endocarditis among injection drug users and nonaddicts: a prospective study of 74 patients. BMC Infectious Diseases (Sept.) 6:137.
KONDELL, P. A., Nord, C.E., Nordenram, G. (1984). Characterization of Staphylococcus aureus isolates from oral surgical outpatients compared to isolates from hospitalized andnnon hospitalized individuals. Int J Oral Surg; 13:(416-22).
CHIA-Yu, C., Shih-Min, W., Chia-Chun, L., and Ching-Chuan, L. (2010). Microbiological Characteristics of Community-Associated Staphylococcus aureus Causing Uncomplicated Bacteremia and Infective Endocarditis. Journal of Clinical Microbiology (Jan.) 48(1):(292-294).
BAENA, T., Moreno, V., Franco, F., Aldape, B., Quindós, G., Sánchez, L. (2005). Colonizacion por candida albicans, Staphylococcus aureus y Streptococcus mutans en pacientes portadores de prótesis dental. Med Oral Patol Oral Cir Bucal, 10:(E27-E399.
OHARA-Nemoto, Y., Haraga, H., Kimura, S., and Nemoto, T.K. (2008). Ocurrence of Staphylococccus in the oral cavities of healthy adults and nasal-oral trafficking of the bacteria. Journal of Medical Microbiology, 57:(95-99).
DIZ Dios, P., Tomás Carmona I, Limeres Posse J, Medina Henríquez, J., Fernández Feijoo, J., Álvarez Fernández, M. (2006). Comparative efficacies of amoxicillin, clindamycin, and moxifloxacin in prevention of bacteremia following dental extractions. Antimicrob Agents Chemother (Sep.), 50(9):(2996-3002).
BERRINGTON, A.W., Koerner, R.J., Perry, J.D., Bain, H.H., Gould, F.K. (2001). Treatment of Staphylococcus aureus endocarditis using moxifloxacin. Int. J. Med. Microbiol. (May.), 291:(237-239).
POVEDA, R., Jiménez, Y., Carbonell, E., Gavaldá, C., Margaix, M., Muñoz, M., Sarrión, G. (2008). Bacteremia originating in the oral cavity. A review Med Oral Patol Oral Cir Bucal. (Jun.), 1;13(6):(E355-62).
GALANI, L., Pefanis, A., Sakka, V., Iliopoulos, D., Donta, I., Triantafylllidi, H., Skiadas, I., Karayiannakpos, Giamarellou, H. (2009). Successful treatment with moxifloxacin of experimental aortic valve endocarditis due to methicillin-resistant Staphylococcus aureus (MRSA) Interntional Journal of Antimicrobial Agents 33:(65-69).
GROPPO, F. C. Castro, F. M, Pacheco, A. B., Motta, R. H., Filho, T.R., Ramacciato, J. C., Florio, F. M., Meechan, J. G. (2005). Antimicrobial resistance of Staphylococcus aureus and oral Streptococci strain from high-risk endocarditis patients. Gen Dent. (Nov.-Dec.) 53(6):(410-3).
BLANCO-Carrión, A. (2004). Bacterial endocarditis prophylaxis. Med Oral Patol Oral Cir Bucal, 9 Suppl:S37-51.
LOZANO, D., Díaz, L., Echeverry, M., Pineda, S., Mattar, S. (2010). Staphylococcus aureus resisstrente a meticilina (SAMR) positivos para PVL asilados en individuos sanos de Montería-Córdoba. Universitas SCIENTIARUM 53 (15):(159-165).
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